USF2 and PPARGC1A

Number of citations of the paper that reports this interaction (PubMedID 12611894)
9

Data Source:
HPRD (in vivo, in vitro)

		USF2	PPARGC1A
Description		upstream transcription factor 2, c-fos interacting	PPARG coactivator 1 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Cell Nucleus Nucleoplasm Nuclear Euchromatin PML Body Cytosolic Ribosome Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Dendrite Subsarcolemmal Mitochondrion Interfibrillar Mitochondrion
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peroxisome Proliferator Activated Receptor Binding Alpha-tubulin Binding Sequence-specific DNA Binding Androgen Receptor Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Transcription By RNA Polymerase II Lactation Late Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis	Response To Reactive Oxygen Species Autophagy Of Mitochondrion Temperature Homeostasis Cellular Glucose Homeostasis Negative Regulation Of Protein Phosphorylation Response To Dietary Excess Response To Ischemia Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Aging Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Skeletal Muscle Atrophy Response To Muscle Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Cerebellum Development Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Forebrain Development Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Cellular Response To Potassium Ion Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Flavone Metabolic Process Adipose Tissue Development Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Nitrite Cellular Response To Caffeine Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Response To Norepinephrine Negative Regulation Of Mitochondrial Fission Energy Homeostasis Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Metformin Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process Cellular Response To Ionomycin Cellular Response To Resveratrol Response To Methionine Adaptive Thermogenesis Positive Regulation Of Progesterone Biosynthetic Process Negative Regulation Of Signaling Receptor Activity Regulation Of NMDA Receptor Activity Positive Regulation Of ATP Biosynthetic Process
Pathways		Estrogen-dependent gene expression	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red cell distribution width ( 27863252 28957414)	Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		10 interacting genes: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A RELA TEAD2 USF1	42 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2
Entrez ID		7392	10891
HPRD ID		02668	05155
Ensembl ID		ENSG00000105698	ENSG00000109819
Uniprot IDs		Q15853	A0A024R9Q9 Q9UBK2
PDB IDs			1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6NWK 6NWL
Enriched GO Terms of Interacting Partners?
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