USF1 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 12791656)
26

Data Source:
HPRD (in vivo, in vitro)

		USF1	NFYA
Description		upstream transcription factor 1	nuclear transcription factor Y subunit alpha
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Hypoxia Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To UV Late Viral Transcription Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Lipid Homeostasis	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Estrogen-dependent gene expression	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases		Familial combined hyperlipidemia (FCHL)
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Metabolite levels (lipoprotein measures) ( 27005778) Night sleep phenotypes ( 27126917)	White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: APP ESR1 FBXO7 FOS FOSL1 GTF2I HDAC9 NFYA PLEKHF2 PPARGC1A PRKDC TAOK2 TCF3 TCFL5 TRAF2 USF2	42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		7391	4800
HPRD ID		01880	01793
Ensembl ID		ENSG00000158773	ENSG00000001167
Uniprot IDs		A0A0S2Z4U5 P22415	A0A024RD22 P23511
PDB IDs		1AN4	4AWL 6QMP
Enriched GO Terms of Interacting Partners?
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