UBE2H and UBASH3B

Number of citations of the paper that reports this interaction (PubMedID 17588522)
59

Data Source:
BioGRID (enzymatic study)

		UBE2H	UBASH3B
Description		ubiquitin conjugating enzyme E2 H	ubiquitin associated and SH3 domain containing B
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GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Tyrosine Phosphatase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Signal Transduction Peptidyl-tyrosine Dephosphorylation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Protein Binding Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Response to antidepressants and depression ( 27622933)	Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 24097068 25961943 20686565) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) HDL cholesterol ( 24097068 20686565) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		67 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 UBA1 UBASH3B UBOX5 UBR2 UBR3	27 interacting genes: CBL CBLB CUL3 DAZAP2 DMRT3 DOC2A FAM168A JAK2 KHDRBS1 MAP3K1 PKP4 PRKN RCHY1 RNF41 SHC1 SLC25A48 SPRY2 SYK UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B
Entrez ID		7328	84959
HPRD ID		03052	16463
Ensembl ID		ENSG00000186591	ENSG00000154127
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q8TF42
PDB IDs		2Z5D	2CPW 2E5K 5VR6 5W5G
Enriched GO Terms of Interacting Partners?
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