TYR and TYRP1

Number of citations of the paper that reports this interaction (PubMedID 14623273)
5

Data Source:
HPRD (in vivo)

		TYR	TYRP1
Description		tyrosinase	tyrosinase related protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi-associated Vesicle Cytosol Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle
	Molecular Function	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Protein Homodimerization Activity	Monophenol Monooxygenase Activity Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Proliferation Response To UV Response To Vitamin D Melanin Biosynthetic Process Pigmentation Thymus Development Response To CAMP Oxidation-reduction Process	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Pigmentation Positive Regulation Of Melanin Biosynthetic Process Oxidation-reduction Process
Pathways		Melanin biosynthesis	Melanin biosynthesis
Drugs		NADH Azelaic Acid Monobenzone Mimosine Hydroquinone
Diseases		Oculocutaneous albinism (OCA)	Oculocutaneous albinism (OCA)
GWAS		Age-related macular degeneration ( 23326517) Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 17952075) Brown vs. black hair color ( 30531825) Cutaneous squamous cell carcinoma ( 27424798) Eye color ( 20585627) Eye color (brightness) ( 30664655) Freckles ( 17952075) Hair color ( 30664655 29662168 26926045) Intraocular pressure ( 29617998) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Macular thickness ( 30535121) Melanoma ( 21983787 28212542 24980573 19578364) Neurociticism ( 29500382) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Optic disc size ( 31809533) Skin pigmentation ( 31315583 30664655 17999355) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 27723757 22561518)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Eye color ( 23548203 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Psoriasis ( 30921485) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		1 interacting genes: TYRP1	2 interacting genes: GIPC1 TYR
Entrez ID		7299	7306
HPRD ID		06086	00283
Ensembl ID		ENSG00000077498	ENSG00000107165
Uniprot IDs		L8B082 P14679	P17643
PDB IDs			5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T
Enriched GO Terms of Interacting Partners?
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