TRPS1 and RNF4

Number of citations of the paper that reports this interaction (PubMedID 12885770)
17

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TRPS1	RNF4
Description		transcriptional repressor GATA binding 1	ring finger protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding	DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of Chondrocyte Differentiation	Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways			Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Trichorhinophalangeal dysplasia
GWAS		Asthma ( 29273806) Basal cell carcinoma ( 31174203) Bronchopulmonary dysplasia ( 23897914) C-reactive protein levels ( 30388399) Cholesterol, total ( 20686565) Chronotype ( 30696823) Cognitive decline (age-related) ( 28078323) Cutaneous squamous cell carcinoma ( 27424798) Disability (impaired activities of daily living) ( 31707593) Diverticular disease ( 30177863) Eating disorders ( 22911880) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High density lipoprotein cholesterol levels ( 29403010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Low tan response ( 29739929) Major depressive disorder ( 22472876) Male-pattern baldness ( 28196072) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Morning person ( 30696823) Night sleep phenotypes ( 27126917) Parkinson's disease (familial, age at onset) ( 27402877) Periodontal microbiota ( 22699663) Platelet count ( 29403010) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Red blood cell count ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Severe influenza A (H1N1) infection ( 26379185) Squamous cell carcinoma ( 31174203) Total cholesterol levels ( 29403010 30275531) Urate levels (BMI interaction) ( 25811787)	Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: RNF4 SUMO1 UBE2I	39 interacting genes: AR ATXN1 ESR1 GSC2 H3C14 HMGA1 HNF4A IKBKG PATZ1 PGR SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TERF2 TRAIP TRIM28 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UEVLD
Entrez ID		7227	6047
HPRD ID		05091	04167
Ensembl ID		ENSG00000104447	ENSG00000063978
Uniprot IDs		Q9UHF7	P78317
PDB IDs			2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?
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