TRH and CPE

Number of citations of the paper that reports this interaction (PubMedID 12270926)
20

Data Source:
HPRD (in vivo)

		TRH	CPE
Description		thyrotropin releasing hormone	carboxypeptidase E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Thyrotropin-releasing Hormone Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Histamine Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Peptide Metabolic Process Neuropeptide Signaling Pathway Wnt Signaling Pathway Protein Processing Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Localization To Membrane
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Insulin processing
Drugs			Insulin Human Insulin Pork
Diseases
GWAS		Alzheimer's disease ( 30636644) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: ARRB2 CPE TRHR	17 interacting genes: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		7200	1363
HPRD ID		08944	00272
Ensembl ID		ENSG00000170893	ENSG00000109472
Uniprot IDs		P20396	A0A384N679 P16870
PDB IDs
Enriched GO Terms of Interacting Partners?
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