TRAF6 and POLI

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRAF6	POLI
Description		TNF receptor associated factor 6	DNA polymerase iota
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Plasma Membrane Receptor Complex	Intracellular Nucleoplasm Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Protein Deubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-2 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc-epsilon Receptor Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Transcription Regulatory Region DNA Binding	DNA Replication DNA Repair Translesion Synthesis Error-prone Translesion Synthesis
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane	Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)	Asthma ( 31361310 30929738) Asthma (childhood onset) ( 30929738) Inflammatory skin disease ( 25574825)
Interacting Genes		163 interacting genes: ABL1 APP ATM ATP6V1E1 ATXN3 BCL3 BEX3 BMPR1B CALCOCO2 CASP8 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FHL2 FYN GART GSK3B GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR NGFR NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PELI3 PFN1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RIPK2 RNF114 RNF31 RPL3 RPS2 RPS20 RPS27A SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK26 STRADB STUB1 SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TMEM189-UBE2V1 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UEVLD USP1 USP15 USP2 USP21 USP39 USP5 USP7 VPS52 XIAP YBX1 YES1 YWHAQ ZFAND5 ZMYND11 ZNF675 ZRANB1	20 interacting genes: APP CALCOCO2 DAZAP2 DVL2 EP300 MFHAS1 MTNR1B NEDD8 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC ZBTB44
Entrez ID		7189	11201
HPRD ID		03833	16094
Ensembl ID		ENSG00000175104	ENSG00000101751
Uniprot IDs		Q9Y4K3	Q9UNA4
PDB IDs		1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33	1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 2MBB 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2 5KT2 5KT3 5KT4 5KT5 5KT6 5KT7 5ULW 5ULX
Enriched GO Terms of Interacting Partners?
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