TP53BP1 and DCLRE1A

Number of citations of the paper that reports this interaction (PubMedID 12446782)
18

Data Source:
HPRD (in vivo)

		TP53BP1	DCLRE1A
Description		tumor protein p53 binding protein 1	DNA cross-link repair 1A
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex	Nuclear Chromosome, Telomeric Region Fibrillar Center Nucleoplasm
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding P53 Binding Damaged DNA Binding Transcription Coregulator Activity Protein Binding Methylated Histone Binding Telomeric DNA Binding Histone Binding Ubiquitin Modification-dependent Histone Binding	Damaged DNA Binding 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Protein Homooligomerization Cellular Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protection From Non-homologous End Joining At Telomere Interstrand Cross-link Repair Cell Division Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Cardiometabolic and hematological traits ( 27668658) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lung cancer in ever smokers ( 28604730) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		42 interacting genes: ARAP1 ATM BLM BRCA1 BRCA2 CCNB1 CDK1 CHEK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AX H4-16 H4C14 IFI16 KAT8 KDM1A LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16L1 PAXIP1 PCNT RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SUMO2 TFDP1 TP53 USP28 VAC14	2 interacting genes: PIAS1 TP53BP1
Entrez ID		7158	9937
HPRD ID		05569	08519
Ensembl ID		ENSG00000067369	ENSG00000198924
Uniprot IDs		A6NNK5 Q12888	Q6PJP8
PDB IDs		1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT	4B87 5AHR 5NZW 5NZX 5NZY 5Q1J 5Q1K 5Q1L 5Q1M 5Q1N 5Q1O 5Q1P 5Q1Q 5Q1R 5Q1S 5Q1T 5Q1U 5Q1V 5Q1W 5Q1X 5Q1Y 5Q1Z 5Q20 5Q22 5Q23 5Q24 5Q25 5Q26 5Q27 5Q28 5Q29 5Q2A 5Q2B 5Q2C 5Q2D 5Q2E 5Q2F 5Q2G 5Q2H 5Q2I 5Q2J 5Q2K 5Q2L 5Q2M 5Q2N 5Q2O 5Q2P 5Q2Q 5Q2R 5Q2S 5Q2T 5Q2U 5Q2V 5Q2W 5Q2X 5Q2Y 5Q2Z 5Q30 5Q31 5Q32 5Q33 5Q34 5Q35 5Q36 5Q37 5Q38 5Q39 5Q3A 5Q3B 5Q3C 5Q3D 5Q3E 5Q3F 5Q3G 5Q3H 5Q3I 5Q3J 5Q3K 5Q3L 5Q3M 5Q3N 5Q3O 5Q3P 5Q3Q 5Q3R 5Q3S 5Q3T 5Q3U 5Q3V 5Q3W 5Q3X 5Q3Y 5Q3Z 5Q40 5Q41 5Q42 5Q43 5Q44 5Q45 5Q46 5Q47 5Q48 5Q49 5Q4A 5Q4B 5Q4C 5Q4D 5Q4E 5Q4F 5Q4G 5Q4H 5Q4I 5Q4J 5Q4K 5Q4L 5Q4M 5Q4N 5Q4O 5Q4P 5Q4Q 5Q4R 5Q4S 5Q4T 5Q4U 5Q4V 5Q4W 5Q4X 5Q4Y 5Q4Z 5Q50 5Q51 5Q52 5Q53 5Q54 5Q55 5Q56 5Q57 5Q58 5Q59 5Q5A 5Q5B 5Q5C 5Q5D 5Q5E 5Q5F 5Q5G 5Q5H 5Q5I 5Q5J 5Q5K 5Q5L 5Q5M 5Q5N 5Q5O 5Q5P 5Q5Q 5Q5R 5Q5S 5Q5T 5Q5U 5Q5V 5Q5W 5Q5X 5Q5Y 5Q5Z 5Q60 5Q61 5Q62 5Q63 5Q64 5Q65 5Q66 5Q67 5Q68 5Q69 5Q6A 5Q6B 5Q6C 5Q6D 5Q6E 5Q6F 5Q6G 5Q6H 5Q6I 5Q6J 5Q6K 5Q6L 5Q6M 5Q6N 5Q6O 5Q6P 5Q6Q 5Q6R 5Q6S 5Q6T 5Q6U 5Q6V 5Q6W 5Q6X 5Q6Y 5Q6Z 5Q70 5Q71 5Q72 5Q73 5Q74 5Q75 5Q76 5Q77 5Q78 5Q79 5Q7A 5Q7B 5Q7C 5Q7D 5Q7E 5Q7F 5Q7G 5Q7H 5Q7I 5Q7J 5Q7K 5Q7L 5Q7M 5Q7N 5Q7O 5Q7P 5Q7Q 5Q7R 5Q7S 5Q7T 5Q7U 5Q7V 5Q7W 5Q7X 5Q7Y 5Q7Z 5Q80 5Q81 5Q82 5Q83 5Q84 5Q85 5Q86 5Q87 5Q88 5Q89 5Q8A 5Q8B 5Q8C 5Q8D 5Q8E 5Q8F 5Q8G 5Q8H 5Q8I 5Q8J 5Q8K 5Q8L 5Q8M 5Q8N 5Q8O 5Q8P 5Q8Q 5Q8R 5Q8S 5Q8T 5Q8U 5Q8V 5Q8W 5Q8X 5Q8Y 5Q8Z 5Q90 5Q91 5Q92 5Q93 5Q94 5Q95 5Q96 5Q97 5Q98 5Q99 5Q9A 5Q9B 5Q9C 5Q9D 5Q9E 5Q9F 5Q9G 5Q9H 5Q9I 5Q9J 5Q9K 5Q9L 5Q9M 5Q9N 5Q9O 5Q9P 5Q9Q 5Q9R 5Q9S 5Q9T 5Q9U 5Q9V 5Q9W 5Q9X 5Q9Y 5Q9Z 5QA0 5QA1 5QA2
Enriched GO Terms of Interacting Partners?
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