C1QC and PTX3

Number of citations of the paper that reports this interaction (PubMedID 12645945)
76

Data Source:
HPRD (in vitro)

		C1QC	PTX3
Description		complement C1q C chain	pentraxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Protein Binding	Complement Component C1q Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Neutrophil degranulation
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc Copper
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576 29875488)	Body mass index ( 26426971)
Interacting Genes		5 interacting genes: C1QA C1QB FKBP2 PTX3 RALA	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		714	5806
HPRD ID		00395	03928
Ensembl ID		ENSG00000159189	ENSG00000163661
Uniprot IDs		A0A024RAA7 P02747	P26022
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ
Enriched GO Terms of Interacting Partners?
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