SERPING1 and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		SERPING1	SLC30A2
Description		serpin family G member 1	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Cytoplasm Lysosomal Membrane Late Endosome Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response	Response To Zinc Ion Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade	Zinc efflux and compartmentalization by the SLC30 family
Drugs		C1-INH Copper
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	11 interacting genes: ADAM33 CCL4 CCL4L2 CD99L2 CREB3 KASH5 LMNA LTA PVR SERPING1 TNFRSF12A
Entrez ID		710	7780
HPRD ID		06033	18057
Ensembl ID		ENSG00000149131	ENSG00000158014
Uniprot IDs		E9KL26 P05155	Q9BRI3
PDB IDs		1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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