TIAM1 and MYC

Number of citations of the paper that reports this interaction (PubMedID 12446731)
9

Data Source:
HPRD (in vivo, in vitro)

		TIAM1	MYC
Description		TIAM Rac1 associated GEF 1	MYC proto-oncogene, bHLH transcription factor
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GO Annotations	Cellular Component	Nucleus Cytosol Microtubule Plasma Membrane Cell-cell Junction Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuronal Cell Body Dendritic Spine Cell-cell Contact Zone Axonal Growth Cone Main Axon Synapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nuclear Chromatin Cell Nucleus Nucleoplasm Nucleolus Protein-containing Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Lipid Binding Kinase Binding Rac Guanyl-nucleotide Exchange Factor Activity Receptor Tyrosine Kinase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein-containing Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding
	Biological Process	Cardiac Muscle Hypertrophy Apoptotic Process Cell-matrix Adhesion G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Protein Binding Cellular Protein-containing Complex Assembly Response To Cocaine Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Activation Of GTPase Activity NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Schwann Cell Chemotaxis Regulation Of Dopaminergic Neuron Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Projection Extension Regulation Of Non-canonical Wnt Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Cell Proliferation Response To Gamma Radiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Oxygen Transport Protein Deubiquitination Cytokine-mediated Signaling Pathway Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Telomerase Activity ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Regulation Of Somatic Stem Cell Population Maintenance Beta-catenin-TCF Complex Assembly Positive Regulation Of DNA Methylation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events Activated NTRK2 signals through CDK5	Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs			Nadroparin
Diseases			Choriocarcinoma Penile cancer Burkitt lymphoma Oral cancer Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Multiple myeloma Small cell lung cancer Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Osteosarcoma Kaposi's sarcoma Laryngeal cancer Breast cancer Ovarian cancer
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Alcohol use disorder ( 30940813) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Bladder cancer ( 20972438) Breast cancer ( 29059683 23535729) Chronic lymphocytic leukemia ( 23770605) Colorectal cancer ( 25990418 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diffuse large B cell lymphoma ( 25261932) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Glioblastoma ( 29743610) Glioma ( 29743610) Height ( 25429064) Multiple sclerosis ( 21833088) Non-glioblastoma glioma ( 29743610) Nonsyndromic cleft lip with cleft palate ( 28232668) Ovarian cancer ( 23535730 20852632) Pancreatic cancer ( 29422604 27579533 25086665) Prostate cancer ( 24753544) Prostate cancer (early onset) ( 24740154) Prostate-specific antigen levels ( 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Renal cell carcinoma ( 24220699) Urinary bladder cancer ( 20348956 18794855 24861552)
Interacting Genes		31 interacting genes: ABCA1 ANK1 BTRC CAMK2G CD44 CSNK1A1 EFNB1 EPHA2 FNDC3B HRAS MAPK8IP1 MAPK8IP2 MYC NME1 OSBPL1A PARD3 PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 SRC SRSF5 SYCP1 UBC YWHAG ZKSCAN4	176 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CALM1 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK4 CDK6 CDK8 CDK9 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 EP300 EP400 EPHA2 ERBB2 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2F2 GTF2I HGF HIF1A HSP90AA1 ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MSH2 MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NSD3 NUCB1 PAK2 PARP10 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 RUVBL1 RUVBL2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIM6 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP2 USP22 USP36 USP37 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281
Entrez ID		7074	4609
HPRD ID		02820	01818
Ensembl ID		ENSG00000156299	ENSG00000136997
Uniprot IDs		A0A2X0TW27 Q13009	P01106
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L
Enriched GO Terms of Interacting Partners?
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