TGFB2 and ENG

Number of citations of the paper that reports this interaction (PubMedID 12015308)
61

Data Source:
HPRD (in vitro, in vivo)

		TGFB2	ENG
Description		transforming growth factor beta 2	endoglin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Platelet Alpha Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Cell Morphogenesis Skeletal System Development Eye Development Response To Hypoxia Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Hair Follicle Development Platelet Degranulation Heart Morphogenesis Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Heart Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Neural Retina Development Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Cell Death Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Male Gonad Development Response To Wounding Embryo Development Ending In Birth Or Egg Hatching Cardioblast Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Ascending Aorta Morphogenesis Wound Healing Regulation Of Cell Proliferation Dopamine Biosynthetic Process Odontogenesis Response To Drug Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Negative Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Development Generation Of Neurons Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Positive Regulation Of Cell Division Regulation Of Timing Of Catagen Positive Regulation Of Timing Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Uterus Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Secondary Palate Development Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Complement-dependent Cytotoxicity Substantia Propria Of Cornea Development Cranial Skeletal System Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Chronological Cell Aging Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Response To Drug Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta Endocardial Cushion To Mesenchymal Transition Vascular Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans
Drugs
Diseases		Graft-versus-host disease Allograft rejection	Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Acne (severe) ( 24927181 30542056) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density (hip) ( 30172743) Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease (severe) ( 24621683) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 25673412) Hip minimal joint space width ( 27701424) Intraocular pressure ( 29617998) Local histogram emphysema pattern ( 25006744) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148)
Interacting Genes		16 interacting genes: APP BMP2 CCN2 DCN ENG FMOD LTBP3 MARK1 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	14 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL GDF2 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		7042	2022
HPRD ID		01828	00565
Ensembl ID		ENSG00000092969	ENSG00000106991
Uniprot IDs		P61812 Q59EG9	A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		1TFG 2TGI 4KXZ 5TX4 5TY4 6I9J	5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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