TERT and FOXO3

Number of citations of the paper that reports this interaction (PubMedID 26370108)
20

Data Source:
BioGRID (pull down)

		TERT	FOXO3
Description		telomerase reverse transcriptase	forkhead box O3
Image
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cofactor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Sequence-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Telomere Maintenance Transcription, RNA-templated RNA-dependent DNA Biosynthetic Process Telomere Maintenance Via Telomerase Mitochondrion Organization Negative Regulation Of Gene Expression DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Regulation Of Protein Stability Positive Regulation Of Protein Binding Positive Regulation Of Hair Cycle Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Glucose Import Response To Cadmium Ion Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Glial Cell Proliferation Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Transdifferentiation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Beta-catenin-TCF Complex Assembly Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Aging Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy Cytokine-mediated Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Glucose Homeostasis Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brain Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Corticosterone Stimulus Cellular Response To Hypoxia Response To Dexamethasone Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus Response To Water-immersion Restraint Stress Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex	Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Zidovudine Grn163l Tertomotide
Diseases		Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Basal cell carcinoma ( 31174203 19151717 24403052 25855136) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 24163127 20972438) Breast cancer ( 22037553 29059683 23535729 23535733 27117709 28171663) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 28165464 26956414) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) EGFR mutation-positive lung adenocarcinoma ( 27501781) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21827660 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 31171785) Lung adenocarcinoma ( 20700438 28604730 19836008 22797724 20871597 27393504) Lung cancer ( 21725308 23143601 27393504 18978790) Lung cancer in never smokers ( 31009812 28604730) Mean corpuscular hemoglobin ( 29403010 27863252 28017375) Mean corpuscular volume ( 29403010 27863252 28017375) Melanoma ( 21983787 28212542) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Nasopharyngeal carcinoma ( 27436580 26545403) Neutrophil count ( 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 29422604 27579533 25086665) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Prostate cancer ( 31562322 21743467 25939597) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 29403010 20139978 27863252) Serum prostate-specific antigen levels ( 21160077) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 29403010 27863252)	Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		80 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MDM2 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	27 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 HDAC2 IKBKB MAPK1 MAPK6 NR1H2 NR1H3 PTPA SGK1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ
Entrez ID		7015	2309
HPRD ID		01754	04061
Ensembl ID		ENSG00000164362	ENSG00000118689
Uniprot IDs		O14746	O43524
PDB IDs		2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW	2K86 2LQH 2LQI 2UZK 6MNL
Enriched GO Terms of Interacting Partners?
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