TEC and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 11013262)
10

Data Source:
HPRD (in vivo)

		TEC	PTPN21
Description		tec protein tyrosine kinase	protein tyrosine phosphatase non-receptor type 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Cytoplasm Cytoskeleton
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Prudent dietary pattern ( 28644415)
Interacting Genes		31 interacting genes: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG FBXO7 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS	7 interacting genes: AKAP1 BMX ERBB4 KIF1C SRC TEC YAP1
Entrez ID		7006	11099
HPRD ID		02786	04468
Ensembl ID		ENSG00000135605	ENSG00000070778
Uniprot IDs		P42680	Q16825
PDB IDs		2LUL
Enriched GO Terms of Interacting Partners?
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