MLX and MAD1L1

Number of citations of the paper that reports this interaction (PubMedID 10593926)
30

Data Source:
HPRD (two hybrid, in vitro)

		MLX	MAD1L1
Description		MAX dimerization protein MLX	mitotic arrest deficient 1 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926)	Adverse response to drug ( 30420678) Age at first sexual intercourse ( 27089180) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 28115744 21926972 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dimensional psychopathology (Social) ( 29496196) Gastroesophageal reflux disease ( 31527586) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Number of sexual partners ( 30643258) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		14 interacting genes: APP GABARAPL2 ID3 LNX2 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP TLE5 ZBTB32	40 interacting genes: ALOX5 AMOTL2 BIRC2 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PML PSMA1 RNF8 SIN3A SIN3B SPATA2 SUPT5H TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		6945	8379
HPRD ID		04278	04065
Ensembl ID		ENSG00000108788	ENSG00000002822
Uniprot IDs		Q9UH92	Q9Y6D9
PDB IDs			1GO4 4DZO
Enriched GO Terms of Interacting Partners?
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