TCF3 and MDFI

Number of citations of the paper that reports this interaction (PubMedID 11238923)
24

Data Source:
HPRD (in vitro)

		TCF3	MDFI
Description		transcription factor 3	MyoD family inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Hodgkin's lymphoma ( 29196614 24920014) Objective response to lithium treatment ( 26503763)	Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1	243 interacting genes: AANAT AASDHPPT ABCF3 ABHD17A ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAHD1 BANP BBS2 BCL6 BEX1 C10orf62 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC198 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHRNG CLPB CNNM3 CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FNDC11 FOXD4L6 FZD9 GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 INTS11 IQUB KANSL1 KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LAMB3 LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGED1 MAGEF1 MAPKBP1 MCM5 MEOX2 METTL17 MFSD3 MGAT5B MRPL20-AS1 MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NECTIN2 NEU4 NOL4L-DT NPDC1 NR1H2 NR1H3 NTAQ1 ODAPH OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PRPF31 PTPMT1 RABL6 REG3A REX1BD RFX2 RIPPLY1 RNF6 RTP5 SERF2 SFI1 SHFL SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCF3 TEAD4 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TTC23 TTC25 TTLL10 TUSC2 TYMSOS TYRO3 USP20 USP6 VHL VPS72 WDFY3 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF688 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		6929	4188
HPRD ID		00918	07280
Ensembl ID		ENSG00000071564	ENSG00000112559
Uniprot IDs		A0A0A0MRB7 P15923 X6REB3	A0A024RCY2 B1AKB6 Q99750
PDB IDs		1HLH 2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?
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