TAF1 and APC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		TAF1	APC
Description		TATA-box binding protein associated factor 1	APC regulator of WNT signaling pathway
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane Catenin Complex Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Perinuclear Region Of Cytoplasm Wnt Signalosome
	Molecular Function	P53 Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity TBP-class Protein Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity H3K27me3 Modified Histone Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Lysine-acetylated Histone Binding Acetyl-CoA Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding
	Biological Process	Protein Polyubiquitination DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Viral Process Histone Acetylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Midbrain Development Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Transcription Factor Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Response To ATP Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Activity	Mitotic Cytokinesis Cell Fate Specification Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Cell Adhesion Pattern Specification Process Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Death Wnt Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Bicellular Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Centrosome Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Drugs
Diseases			Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)
Interacting Genes		47 interacting genes: APC AR ASF1A ASF1B BRMS1 CCNA2 CCND1 EDF1 EWSR1 FOS GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 JUN MAX MDM2 MSX1 PAX3 PDZD11 RANBP2 RB1 RBL1 RBL2 RELA SPTAN1 SUB1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 UBE2I UBTF	123 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNA1 CTNNB1 CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TPR TRIM21 TRIM25 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID		6872	324
HPRD ID		02436	01439
Ensembl ID		ENSG00000147133	ENSG00000134982
Uniprot IDs		P21675	P25054 Q4LE70
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM	1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H
Enriched GO Terms of Interacting Partners?
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