AURKC and INCENP

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		AURKC	INCENP
Description		aurora kinase C	inner centromere protein
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome Lateral Element Central Element Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Spermatogenesis Attachment Of Spindle Microtubules To Kinetochore Histone Modification Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Oocyte Development Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle	Mitotic Sister Chromatid Segregation Mitotic Cytokinesis Chromosome Segregation Meiotic Chromosome Condensation Histone Phosphorylation Meiotic Spindle Midzone Assembly Metaphase Plate Congression Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cytokinesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine
Diseases
GWAS			Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: BIRC5 BRCA1 CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2	11 interacting genes: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14 MARK2
Entrez ID		6795	3619
HPRD ID		04605	05103
Ensembl ID		ENSG00000105146	ENSG00000149503
Uniprot IDs		Q9UQB9	Q9NQS7
PDB IDs		6GR8 6GR9	2QFA 4AF3 5IEH 5IEK 6GR8 6GR9
Enriched GO Terms of Interacting Partners?
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