STAR and LIPE

Number of citations of the paper that reports this interaction (PubMedID 12925534)
21

Data Source:
HPRD (in vivo, in vitro)

		STAR	LIPE
Description		steroidogenic acute regulatory protein	lipase E, hormone sensitive type
Image			No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Intermembrane Space Cytosol Mitochondrial Crista Neuron Projection Neuronal Cell Body	Lipid Droplet Cytosol Caveola
	Molecular Function	Protein Binding Cholesterol Binding Intermembrane Cholesterol Transfer Activity	Triglyceride Lipase Activity Protein Binding Serine Hydrolase Activity Protein Kinase Binding Hormone-sensitive Lipase Activity
	Biological Process	Steroid Biosynthetic Process Bile Acid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Estrogen Biosynthetic Process Brain Development Response To Nutrient Cholesterol Metabolic Process Glucocorticoid Metabolic Process Male Gonad Development Response To Herbicide Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Gene Expression Response To Activity Diterpenoid Metabolic Process Insecticide Metabolic Process Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Intracellular Cholesterol Transport Cellular Response To Insulin Stimulus Response To Nicotine Cellular Response To Interferon-alpha Response To Hydrogen Peroxide Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Response To Leptin Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Neurogenesis Regulation Of Steroid Biosynthetic Process Response To Corticosterone Response To Fungicide Testosterone Biosynthetic Process Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To Alkaloid Cellular Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Interferon-gamma Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Epinephrine Stimulus	Protein Phosphorylation Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Long-chain Fatty Acid Catabolic Process Diacylglycerol Catabolic Process
Pathways		Pregnenolone biosynthesis	Triglyceride catabolism
Drugs
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Menopause (age at onset) ( 26414677) Orthostatic hypotension ( 24124408) Schizophrenia ( 29483656)
Interacting Genes		6 interacting genes: CCHCR1 FEZ1 LIPE MAGEA11 MAPK3 NUCB2	10 interacting genes: FABP4 KATNA1 MAPK1 MAPK3 MTNR1A NSFL1C PLIN1 PLIN5 PRKACA STAR
Entrez ID		6770	3991
HPRD ID		02794	01062
Ensembl ID		ENSG00000147465	ENSG00000079435
Uniprot IDs		P49675 Q6IBK0	A8K8W7 Q05469
PDB IDs		1IMG 2I93 3P0L 5OMA
Enriched GO Terms of Interacting Partners?
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