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SREBF2 and EGR1
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
85
Data Source:
BioGRID
(two hybrid)
SREBF2
EGR1
Description
sterol regulatory element binding transcription factor 2
early growth response 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nuclear Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Nuclear Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
C-8 Sterol Isomerase Activity
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Histone Acetyltransferase Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Response To Lipid
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Response To Ischemia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Response To Glucose
Positive Regulation Of Gene Expression
T Cell Differentiation
BMP Signaling Pathway
Response To Insulin
Circadian Regulation Of Gene Expression
Regulation Of Protein Sumoylation
Skeletal Muscle Cell Differentiation
Regulation Of Apoptotic Process
Estrous Cycle
Positive Regulation Of Chemokine Biosynthetic Process
Locomotor Rhythm
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Interleukin-1 Beta Biosynthetic Process
Circadian Temperature Homeostasis
Type I Interferon Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Cellular Response To Gamma Radiation
Cellular Response To Heparin
Cellular Response To Mycophenolic Acid
Glomerular Mesangial Cell Proliferation
Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation
Negative Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-8
Positive Regulation Of Neuron Death
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Tau-protein Kinase Activity
Regulation Of Progesterone Biosynthetic Process
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
NGF-stimulated transcription
NGF-stimulated transcription
Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Schizophrenia (
25056061
29483656
)
Amyotrophic lateral sclerosis (C9orf72 mutation interaction) (
22959728
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia (
29274321
)
Schizophrenia (
28991256
25056061
)
Interacting Genes
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SREBF1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
23 interacting genes:
CDKN2A
CEBPB
CRBN
CREBBP
CSNK2A1
DNMT3L
EP300
ERBB3
IL1B
JUN
MTDH
NAB1
NAB2
NFATC1
NFATC2
PITX1
PSMA3
RELA
SP1
SRA1
SREBF2
TP53
WT1
Entrez ID
6721
1958
HPRD ID
02726
00549
Ensembl ID
ENSG00000198911
ENSG00000120738
Uniprot IDs
A0A024R1Q0
Q12772
P18146
Q546S1
PDB IDs
1UKL
4R2A
4R2C
4R2D
4X9J
5N14
Enriched GO Terms of Interacting Partners
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