SREBF1 and HNF4A

Number of citations of the paper that reports this interaction (PubMedID 20817729)
156

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SREBF1	HNF4A
Description		sterol regulatory element binding transcription factor 1	hepatocyte nuclear factor 4 alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Nuclear Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon Response To Lipid MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Type B Pancreatic Cell Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Anatomical Structure Development Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Triglyceride Homeostasis Hepatocyte Differentiation
Pathways		RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Nuclear Receptor transcription pathway
Drugs		Doconexent Omega-3 fatty acids	Lauric Acid AVI-4557 Myristic acid
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Coffee consumption ( 31046077) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860)	C-reactive protein ( 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 27863252) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Pancreatic cancer ( 29422604) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 24509480 30054458 21874001 30297969 29632382 31118516 22158537 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 19915572 23128233) Urate levels ( 31578528)
Interacting Genes		40 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 PLK1 PRMT5 SMARCD3 SP1 SREBF2 SUMO1 TWIST2 UBE2I YY1 ZBTB7C	68 interacting genes: ANP32B ARNT COPS5 CREBBP DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		6720	3172
HPRD ID		01701	02612
Ensembl ID		ENSG00000072310	ENSG00000101076
Uniprot IDs		A8MTU8 B3KR77 P36956	A0A087WXV4 B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1AM9	1PZL 3CBB 3FS1 4B7W 4IQR 6CHT
Enriched GO Terms of Interacting Partners?
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