SPR and CAMK2G

Number of citations of the paper that reports this interaction (PubMedID 11825621)
0

Data Source:
HPRD (in vitro)

		SPR	CAMK2G
Description		sepiapterin reductase	calcium/calmodulin dependent protein kinase II gamma
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Aldo-keto Reductase (NADP) Activity Sepiapterin Reductase Activity NADP Binding	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Oxidation-reduction Process	Protein Phosphorylation Protein Dephosphorylation Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs		Oxaloacetate Ion 2'-Monophosphoadenosine 5'-Diphosphoribose Biopterin N-Acetyl Serotonin	Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS		Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		2 interacting genes: CAMK2G YWHAQ	31 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CHAT CREM EGFR FLNA GRIA1 GRIA4 GRIN1 GRIN2B LRRC7 MYLK PEA15 PLCB3 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 SYN1 TH TIAM1
Entrez ID		6697	818
HPRD ID		01632	03672
Ensembl ID		ENSG00000116096	ENSG00000148660
Uniprot IDs		P35270	A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3
PDB IDs		1Z6Z 4HWK 4J7U 4J7X 4XWY 4Z3K 6I6C 6I6F 6I6P 6I6T 6I6V 6I79	2UX0 2V7O
Enriched GO Terms of Interacting Partners?
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