SPP1 and KCNIP1

Number of citations of the paper that reports this interaction (PubMedID 22779921)
9

Data Source:
BioGRID (two hybrid)

		SPP1	KCNIP1
Description		secreted phosphoprotein 1	potassium voltage-gated channel interacting protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity
	Biological Process	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion	Cardiac Conduction Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)	Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		89 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	5 interacting genes: KCND1 KCND2 KCND3 KCNIP2 SPP1
Entrez ID		6696	30820
HPRD ID		01325	06879
Ensembl ID		ENSG00000118785	ENSG00000182132
Uniprot IDs		A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0	Q9NZI2
PDB IDs		3CXD 3DSF	1S1E 2I2R 2NZ0
Enriched GO Terms of Interacting Partners?
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