SPINT1 and HGFAC

Number of citations of the paper that reports this interaction (PubMedID 11013244)
23

Data Source:
HPRD (in vivo, in vitro)

		SPINT1	HGFAC
Description		serine peptidase inhibitor, Kunitz type 1	HGF activator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Proteolysis
Pathways		MET Receptor Activation Signaling by MST1	MET Receptor Activation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 27989323) Inflammatory bowel disease ( 26192919) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878 30578418) Serum total protein level ( 29403010) Triglyceride levels ( 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)
Interacting Genes		6 interacting genes: HGFAC HMGB1 NLGN3 ST14 TENT5A UBQLN4	5 interacting genes: F2 HGF KLKB1 SPINT1 SPINT2
Entrez ID		6692	3083
HPRD ID		05494	05184
Ensembl ID		ENSG00000166145	ENSG00000109758
Uniprot IDs		O43278	D6RAR4 Q04756
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V	1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?
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