SPINK2 and CEP135

		SPINK2	CEP135
Description		serine peptidase inhibitor Kazal type 2	centrosomal protein 135
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GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region	Centrosome Centriole Cytosol
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Acrosome Assembly Spermatid Development Negative Regulation Of Serine-type Endopeptidase Activity	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Blood protein levels ( 30072576 29875488) Migraine ( 27322543) Post bronchodilator FEV1/FVC ratio ( 26634245) Stroke ( 26089329) Systemic sclerosis ( 30247649)	Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ADAMTSL4 CEP135 KRTAP10-3 KRTAP5-9 MAPK8IP2 NOTCH2NLA	7 interacting genes: CLOCK DCUN1D4 PIBF1 REST SMAD9 SPINK2 USP46
Entrez ID		6691	9662
HPRD ID		10422	11097
Ensembl ID		ENSG00000128040	ENSG00000174799
Uniprot IDs		A0A024RD95 A0A087WTA9 D6RC51 D6RI10 P20155	Q66GS9
PDB IDs		2JXD 6KBR	5FCN 5NG4
Enriched GO Terms of Interacting Partners?
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