FOXL2 and LATS1

Number of citations of the paper that reports this interaction (PubMedID 20407010)
16

Data Source:
BioGRID (enzymatic study)

		FOXL2	LATS1
Description		forkhead box L2	large tumor suppressor kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Intercellular Bridge	Spindle Pole Microtubule Organizing Center Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Estrogen Receptor Binding Ubiquitin Conjugating Enzyme Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Oocyte Growth Extraocular Skeletal Muscle Development Apoptotic DNA Fragmentation Regulation Of Transcription By RNA Polymerase II Single Fertilization Anatomical Structure Morphogenesis Female Somatic Sex Determination Cell Differentiation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Follicle-stimulating Hormone Secretion Embryonic Eye Morphogenesis Granulosa Cell Differentiation Uterus Development	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMOylation of transcription factors	Signaling by Hippo
Drugs
Diseases		Premature ovarian failure Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES)
GWAS		Ear morphology ( 26105758) Eyebrow thickness ( 30248107 26926045) Keloid ( 20711176) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Male-pattern baldness ( 28196072)	Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)
Interacting Genes		3 interacting genes: LATS1 PAK1 UBE2I	45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX
Entrez ID		668	9113
HPRD ID		05723	09147
Ensembl ID		ENSG00000183770	ENSG00000131023
Uniprot IDs		P58012 Q53ZD3	O95835
PDB IDs			4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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