SP100 and ZC2HC1A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SP100	ZC2HC1A
Description		SP100 nuclear antigen	zinc finger C2HC-type containing 1A
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Mre11 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Chromo Shadow Domain Binding	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of Protein Location Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins Interferon gamma signaling
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469) Weight ( 28552196)
Interacting Genes		38 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A	3 interacting genes: APP LASP1 SP100
Entrez ID		6672	51101
HPRD ID		06844	13039
Ensembl ID		ENSG00000067066	ENSG00000104427
Uniprot IDs		P23497 Q6ZMK3	B2R9B8 Q96GY0
PDB IDs		1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P
Enriched GO Terms of Interacting Partners?
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