BNIP3L and ADIPOQ

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		BNIP3L	ADIPOQ
Description		BCL2 interacting protein 3 like	adiponectin, C1Q and collagen domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Membrane Nuclear Speck Intrinsic Component Of Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Mitochondrial Membrane Potential Viral Process Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Defense Response To Virus Negative Regulation Of Cell Death Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Signal Transduction Response To Nutrient Circadian Rhythm Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Cellular Response To Drug Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Protein Homooligomerization Response To Glucocorticoid Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Adiponectin deficiency
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Red cell distribution width ( 27863252) Schizophrenia ( 28991256 30285260)	Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 21700879 26299439 20876611 20011104 22479202 20018283 19165155 24105470) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Blood protein levels ( 30072576) Copper levels ( 26025379)
Interacting Genes		26 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 DOK5 DUSP3 ECM1 EWSR1 FATE1 GBP2 GNB5 KLHL23 LDLRAD1 LMNA MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11	6 interacting genes: ADIPOR2 BNIP3L CDH13 KASH5 SGTA SYNE4
Entrez ID		665	9370
HPRD ID		07288	05671
Ensembl ID		ENSG00000104765	ENSG00000181092
Uniprot IDs		O60238 Q6IBV1	A8K660 B2R773 Q15848
PDB IDs			4DOU
Enriched GO Terms of Interacting Partners?
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