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SUMO2 and MRE11
Number of citations of the paper that reports this interaction (PubMedID
19394292
)
74
Data Source:
BioGRID
(pull down)
SUMO2
MRE11
Description
small ubiquitin like modifier 2
MRE11 homolog, double strand break repair nuclease
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Chromosome, Telomeric Region
Nuclear Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Molecular Function
Transcription Corepressor Binding
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
DNA Helicase Activity
Double-stranded DNA Binding
Nuclease Activity
Endodeoxyribonuclease Activity
Protein Binding
Protein C-terminus Binding
3'-5'-exodeoxyribonuclease Activity
3'-5' Exonuclease Activity
5'-3' Exonuclease Activity
Manganese Ion Binding
Identical Protein Binding
Cadherin Binding
Biological Process
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Sister Chromatid Cohesion
Mitotic G2 DNA Damage Checkpoint
Synapsis
Reciprocal Meiotic Recombination
Cell Proliferation
Viral Process
Intra-S DNA Damage Checkpoint
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Meiotic DNA Double-strand Break Formation
Negative Regulation Of Apoptotic Process
Mitochondrial Double-strand Break Repair Via Homologous Recombination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Vitamin D (calciferol) metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Cytosolic sensors of pathogen-associated DNA
DNA Damage/Telomere Stress Induced Senescence
IRF3-mediated induction of type I IFN
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS
Gamma glutamyl transferase levels (
29403010
)
Interacting Genes
179 interacting genes:
ABRAXAS1
AHNAK
ALAS1
ANAPC2
ANXA1
ATF7IP
ATRX
ATXN7
BABAM2
BAD
BAZ1A
BAZ1B
BLM
BRCC3
C18orf25
CAD
CARS1
CCNE2
CENPC
CHAF1A
CHAF1B
CHAMP1
CHD3
CHD4
CMTM6
CSNK2B
CTNND1
CUL3
CUX1
DAXX
DCD
DDX17
DDX21
DDX3X
DNM1L
EEF1A1
EEF1G
EGLN3
EME1
ENO1
EP300
ERCC4
EXOSC10
EXOSC9
FOS
GATAD2B
HDAC1
HDAC2
HDAC4
HDAC9
HIPK2
HNRNPF
HNRNPH1
HNRNPK
HOMEZ
HP1BP3
HSF2
HSP90AB1
HSPA1A
HSPA8
HSPA9
IPO5
JUN
KALRN
KDM1A
KIF18B
LAS1L
LEF1
MAF1
MAST2
MDC1
MDN1
MKI67
MRE11
MSH2
MSX1
MTA1
MTA2
MUS81
MYB
NBN
NFE2L2
NOL9
NOP2
NUMA1
PARN
PELP1
PFKM
PHF5A
PHF8
PIAS1
PIAS2
PIAS3
PIAS4
PML
POGZ
PRKDC
RAD50
RAD51
RAD54L2
RANBP2
RANGAP1
RBBP4
RBBP7
RCOR1
RCOR2
RCOR3
RNF111
RNF168
RNF216
RNF4
RNF8
RPL3
RPL4
RUVBL1
SAE1
SENP1
SENP2
SENP3
SENP5
SENP6
SENP7
SETDB1
SETX
SIMC1
SLC22A2
SLX4IP
SMCHD1
SOBP
SOX10
SOX6
SP100
SSRP1
SUPT16H
TDG
TDP2
TEAD3
TEX10
TMPO
TNIP1
TOP2A
TOP2B
TOPORS
TP53BP1
TP53BP2
TPR
TRAF1
TRIM26
TRIM28
TRIM63
TRIML2
TUBA1B
TUBB
TUBB4B
TUBB6
UBA2
UBE2I
USP11
USP25
USP28
USP7
USPL1
VIM
WRN
XRCC5
XRCC6
ZBED1
ZBTB2
ZBTB25
ZBTB33
ZCCHC12
ZCCHC7
ZHX1
ZMAT3
ZMYM3
ZMYM4
ZMYM5
ZNF451
ZNF496
19 interacting genes:
ATM
ATR
CCNE1
CDK2
DCLRE1C
DYNLL1
EP300
FANCD2
H2AX
LIG1
MAPK8IP2
NBN
NEK1
PRKDC
RAD50
RECQL5
SPOP
SUMO2
XRCC6
Entrez ID
6613
4361
HPRD ID
04332
02889
Ensembl ID
ENSG00000188612
ENSG00000020922
Uniprot IDs
A0A024R8S3
P61956
A0A024R395
F8W7U8
P49959
Q05D78
PDB IDs
1WM2
1WM3
1WZ0
1Z5Q
2AWT
2CKH
2D07
2IO0
2IO3
2IYD
2N1W
2N9E
2RPQ
3UIN
3UIO
3ZO5
4BKG
4NPN
5D2M
5ELU
5EQL
5GHB
5GHC
3T1I
Enriched GO Terms of Interacting Partners
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