CYP4F12 and SOD2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CYP4F12	SOD2
Description		cytochrome P450 family 4 subfamily F member 12	superoxide dismutase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Iron Ion Binding Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Aromatase Activity	Superoxide Dismutase Activity Manganese Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Sodium Ion Homeostasis Oxidation-reduction Process	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Cellular Response To Oxidative Stress Interleukin-12-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Protein Homotetramerization Oxidation-reduction Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Fatty acids Eicosanoids	Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Benzylsulfinic Acid 3-Fluorotyrosine
Diseases
GWAS			Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Pulse pressure ( 27841878)
Interacting Genes		3 interacting genes: HSPA6 SLC44A2 SOD2	8 interacting genes: APP CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		66002	6648
HPRD ID		07102	00938
Ensembl ID		ENSG00000186204	ENSG00000112096
Uniprot IDs		Q9HCS2	A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59
PDB IDs			1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9
Enriched GO Terms of Interacting Partners?
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