BMX and BCAR1

Number of citations of the paper that reports this interaction (PubMedID 22974441)
10

Data Source:
BioGRID (unspecified method)

		BMX	BCAR1
Description		BMX non-receptor tyrosine kinase	BCAR1 scaffold protein, Cas family member
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Crohn's disease (time to surgery) ( 23665963) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		25 interacting genes: APP BCAR1 BTK C12orf45 CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	56 interacting genes: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		660	9564
HPRD ID		02111	04248
Ensembl ID		ENSG00000102010	ENSG00000050820
Uniprot IDs		P51813	B3KWE2 P56945
PDB IDs		2EKX 2YS2 3SXR 3SXS	1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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