SMARCB1 and CDC23

Number of citations of the paper that reports this interaction (PubMedID 27229929)
3

Data Source:
BioGRID (two hybrid)

		SMARCB1	CDC23
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	cell division cycle 23
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GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein-containing Complex Brahma Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex	Intracellular Cell Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA Repair Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Nervous System Development DNA Integration Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Histone H4-K16 Acetylation	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Fractional shortening ( 29403010) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) N-glycan levels ( 31163085)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		98 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CXCL11 CYB5D2 DNAJA3 DPH6 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HNRNPM HOMEZ HOOK2 HSFY1 IHO1 IKZF3 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MIF4GD MXI1 MYC NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PPP1CC PPP1R15A PRMT5 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RXRA SAXO1 SIN3B SMARCA4 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TSC22D4 UBQLN4 VIM XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398	45 interacting genes: ANAPC10 APOL1 ATRIP BCAS3 BYSL CBY2 CCDC24 CDC16 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DEPDC1B DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 IHO1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SMARCB1 SMUG1 SOX5 SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		6598	8697
HPRD ID		03364	07221
Ensembl ID		ENSG00000099956	ENSG00000094880
Uniprot IDs		G5E975 Q12824 Q9H836	Q9UJX2
PDB IDs		5AJ1 5GJK 5L7A 5L7B 6AX5 6UCH	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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