SLC12A1 and OXSR1

Number of citations of the paper that reports this interaction (PubMedID 12386165)
138

Data Source:
HPRD (two hybrid)

		SLC12A1	OXSR1
Description		solute carrier family 12 member 1	oxidative stress responsive kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Ion Transport Cell Volume Homeostasis Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Protein Phosphorylation Response To Oxidative Stress Osmosensory Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Signal Transduction By Protein Phosphorylation Signal Transduction By Trans-phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium Chloride Hydroflumethiazide Bumetanide Etacrynic acid Trichlormethiazide Quinethazone Piretanide
Diseases		Bartter syndrome
GWAS		Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		3 interacting genes: OXSR1 STK39 TCF12	10 interacting genes: APP BMPR1B GORASP1 PAK1 RELL1 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1
Entrez ID		6557	9943
HPRD ID		02908	06809
Ensembl ID		ENSG00000074803	ENSG00000172939
Uniprot IDs		B4DPF4 Q13621 Q8IUN5	O95747
PDB IDs			2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?
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