NME1-NME2 and NME2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NME1-NME2	NME2
Description		NME1-NME2 readthrough	NME/NM23 nucleoside diphosphate kinase 2
Image
GO Annotations	Cellular Component		Ruffle Extracellular Region Cell Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen
	Molecular Function		DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding
	Biological Process		Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation	Interconversion of nucleotide di- and triphosphates Neutrophil degranulation
Drugs		Guanosine-5'-Diphosphate	Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)
Interacting Genes		2 interacting genes: NME2 NME4	19 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		654364	4831
HPRD ID			01132
Ensembl ID		ENSG00000011052	ENSG00000243678
Uniprot IDs		P22392	F6XY72 P22392 Q6FHN3
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF	1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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