SFTPA1 and PRDX6

Number of citations of the paper that reports this interaction (PubMedID 16330552)
34

Data Source:
BioGRID (pull down)

		SFTPA1	PRDX6
Description		surfactant protein A1	peroxiredoxin 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Lipid Transporter Activity Protein Binding Monosaccharide Binding	Glutathione Peroxidase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Toll-like Receptor Signaling Pathway Lipid Transport Respiratory Gaseous Exchange Opsonization Developmental Process Cellular Protein Metabolic Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Oxidation-reduction Process Cellular Oxidant Detoxification
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	Detoxification of Reactive Oxygen Species Neutrophil degranulation
Drugs		2-(N-Morpholino)-Ethanesulfonic Acid	Isopropyl Alcohol 2-(N-Morpholino)-Ethanesulfonic Acid Copper
Diseases
GWAS			Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		2 interacting genes: DMBT1 PRDX6	19 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD RARA SFTPA1 STH SUMO4 TERF1 TERF2IP UCHL5 YWHAE
Entrez ID		653509	9588
HPRD ID		19256	03817
Ensembl ID		ENSG00000122852	ENSG00000117592
Uniprot IDs		A0A024QZP2 B4DNP6 Q8IWL2	P30041 V9HWC7
PDB IDs			1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?
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