BMP5 and FST

Number of citations of the paper that reports this interaction (PubMedID 11580864)
20

Data Source:
HPRD (in vivo)

		BMP5	FST
Description		bone morphogenetic protein 5	follistatin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Space Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm
	Molecular Function	Cytokine Activity Growth Factor Activity BMP Receptor Binding	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding
	Biological Process	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Pattern Specification Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation BMP Signaling Pathway Male Genitalia Development Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Ear Development Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Pharyngeal System Development SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Anterior Head Development Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Multicellular Organism Development Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of Hair Follicle Development
Pathways			Antagonism of Activin by Follistatin
Drugs			D-Myo-Inositol-Hexasulphate
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Zinc levels ( 26025379)	Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29617998 29235454) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533)
Interacting Genes		4 interacting genes: BMPR1A CHRDL2 FST NOG	9 interacting genes: BMP5 C8orf33 FN1 INHA INHBA INHBE MEST TK1 TXN
Entrez ID		653	10468
HPRD ID		00210	00641
Ensembl ID		ENSG00000112175	ENSG00000134363
Uniprot IDs		A8K694 M9VUD0 P22003	A0A024QZU6 P19883
PDB IDs			2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?
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