UPF3A and UPF1

Number of citations of the paper that reports this interaction (PubMedID 11163187)
218

Data Source:
HPRD (in vivo)

		UPF3A	UPF1
Description		UPF3A regulator of nonsense mediated mRNA decay	UPF1 RNA helicase and ATPase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex Intracellular Membrane-bounded Organelle	Nuclear Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	RNA Binding Protein Binding Structural Constituent Of Nuclear Pore Telomeric DNA Binding	Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Positive Regulation Of Translation MRNA Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Height ( 31562340) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1	36 interacting genes: ABHD16A ACRV1 ACSS2 AP1G1 ATR CNN1 CSNK2B DCP1A DCP2 DHPS DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LDB1 LSM8 NADSYN1 NDRG1 NDUFB10 NOTCH3 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		65110	5976
HPRD ID		09274	03254
Ensembl ID		ENSG00000169062	ENSG00000005007
Uniprot IDs		B3KUE7 Q9H1J1	A0A024R7L5 A0A024R7L8 B3KY55 Q92900
PDB IDs		2L08	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
Enriched GO Terms of Interacting Partners?
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