SLAMF1 and SH2D1B

Number of citations of the paper that reports this interaction (PubMedID 11689425)
33

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SLAMF1	SH2D1B
Description		signaling lymphocytic activation molecule family member 1	SH2 domain containing 1B
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome	Cytosol
	Molecular Function	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Protein Binding Protein Binding, Bridging
	Biological Process	Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Phagocytosis Cell Adhesion Positive Regulation Of Cell Proliferation Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of JNK Cascade Lymphocyte Activation Viral Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)	Takayasu arteritis ( 25604533)
Interacting Genes		6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B	11 interacting genes: APP CD244 CD84 ERBB2 LY9 MAPK8IP2 PRDX1 PTK2 SLAMF1 STAT4 TRIM54
Entrez ID		6504	117157
HPRD ID		04603	12248
Ensembl ID		ENSG00000117090	ENSG00000198574
Uniprot IDs		Q13291	O14796
PDB IDs		1D4T 1D4W 1I3Z 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5	5KAZ
Enriched GO Terms of Interacting Partners?
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