MRPS5 and COMT

		MRPS5	COMT
Description		mitochondrial ribosomal protein S5	catechol-O-methyltransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Dendritic Spine Intracellular Membrane-bounded Organelle Cell Body Postsynaptic Membrane Extracellular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity
	Biological Process	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Response To Drug Response To Estrogen Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase
Drugs			Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
Diseases
GWAS			Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: CD8A CD8B COMT GFPT1 IMMT MGLL NMB NUP153 SOX30	17 interacting genes: ACE BRS3 CDC27 GLP1R HCK HOPX KRT31 KRT40 KRTAP5-9 LITAF MRPS5 MTNR1A RGS2 TRIP13 VKORC1 XRN2 ZNF43
Entrez ID		64969	1312
HPRD ID		10099	00284
Ensembl ID		ENSG00000144029	ENSG00000093010
Uniprot IDs		P82675	A0A140VJG8 P21964
PDB IDs		3J9M 6NU2 6NU3	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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