NMNAT1 and CCNC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NMNAT1	CCNC
Description		nicotinamide nucleotide adenylyltransferase 1	cyclin C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nicotinate metabolism	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Resting heart rate ( 27798624)	Erectile dysfunction ( 30297428)
Interacting Genes		12 interacting genes: APP BANP CCNC FLOT2 KPNA2 MSX1 NEK3 NTRK2 PABPC4 SIK1 SIRT1 TDO2	32 interacting genes: CCNH CDK3 CDK8 CRX DYDC1 ERCC3 ESR1 ESR2 FOXP2 GLYR1 GOLGA2 GPC4 HSPB1 KRT13 KRT15 KRT31 LZTS2 MBIP MCM2 MED8 MEOX2 MGST3 NEFL NMNAT1 PBXIP1 PNMA5 PUF60 RB1 TADA3 TP63 TRIM39 ZNF18
Entrez ID		64802	892
HPRD ID		16369	00456
Ensembl ID		ENSG00000173614	ENSG00000112237
Uniprot IDs		A0A024R4E1 B1AN62 Q9HAN9	P24863 Q7Z4L3
PDB IDs		1GZU 1KKU 1KQN 1KQO 1KR2	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2
Enriched GO Terms of Interacting Partners?
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