BMI1 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 11171983)
91

Data Source:
HPRD (in vivo)

		BMI1	E2F6
Description		BMI1 proto-oncogene, polycomb ring finger	E2F transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Promoter-specific Chromatin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Segment Specification Regulation Of Gene Expression Hemopoiesis Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Penile cancer
GWAS		Prostate-specific antigen levels ( 28139693)	Diisocyanate-induced asthma ( 25918132) Sudden cardiac arrest ( 21658281)
Interacting Genes		37 interacting genes: CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 VPS11 ZBTB16	28 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		648	1876
HPRD ID		01277	04251
Ensembl ID		ENSG00000168283	ENSG00000169016
Uniprot IDs		P35226	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6
Enriched GO Terms of Interacting Partners?
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