EPS8L2 and SASH1

Number of citations of the paper that reports this interaction (PubMedID 30480076)
2

Data Source:
BioGRID (two hybrid)

		EPS8L2	SASH1
Description		EPS8 like 2	SAM and SH3 domain containing 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Vesicle Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Extracellular Exosome	Cytoplasm Protein-containing Complex
	Molecular Function	Actin Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Cadherin Binding	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		7 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		64787	23328
HPRD ID		10940	06408
Ensembl ID		ENSG00000177106	ENSG00000111961
Uniprot IDs		Q9H6S3	O94885
PDB IDs		1WWU 1WXB	2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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