SHB and LCP2

Number of citations of the paper that reports this interaction (PubMedID 12084069)
8

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		SHB	LCP2
Description		SH2 domain containing adaptor protein B	lymphocyte cytosolic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways		VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)	Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		19 interacting genes: ABL1 CRK EPS8 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR LAT LCP2 PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		6461	3937
HPRD ID		02635	03362
Ensembl ID		ENSG00000107338	ENSG00000043462
Uniprot IDs		Q15464	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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