SFTPD and MFAP4

Number of citations of the paper that reports this interaction (PubMedID 10542261)
14

Data Source:
HPRD (in vivo)

		SFTPD	MFAP4
Description		surfactant protein D	microfibril associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Microfibril Extracellular Region Collagen-containing Extracellular Matrix Elastic Fiber
	Molecular Function	Lipopolysaccharide Binding Protein Binding Carbohydrate Binding Identical Protein Binding Monosaccharide Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Respiratory Gaseous Exchange Developmental Process Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Cellular Protein Metabolic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation By Host Of Symbiont Molecular Function Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell	Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	Molecules associated with elastic fibres
Drugs		Beta-D-Glucose
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		4 interacting genes: DCN DMBT1 MFAP4 RBX1	2 interacting genes: RNF115 SFTPD
Entrez ID		6441	4239
HPRD ID		01522	02789
Ensembl ID		ENSG00000133661	ENSG00000166482
Uniprot IDs		P35247	A0A024QZ34 P55083
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?
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