SIL1 and CCND3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SIL1	CCND3
Description		SIL1 nucleotide exchange factor	cyclin D3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Unfolded Protein Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Folding Intracellular Protein Transport Regulation Of Catalytic Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity
Drugs
Diseases
GWAS			Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 23263863 29403010 28453575 20139978 27863252 28017375 19862010) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 21507922) Red blood cell count ( 29403010 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		9 interacting genes: CCND3 GHRL HSPA5 NPM1 PCDHB16 RFK SETD7 SMAD9 UBQLN1	46 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C CASP2 CDK11B CDK14 CDK4 CDK6 CDKN1A CDKN1B CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC LSM3 MAF1 MAPK4 MAPK6 MCM10 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR
Entrez ID		64374	896
HPRD ID		12150	00452
Ensembl ID		ENSG00000120725	ENSG00000112576
Uniprot IDs		A0A0S2Z6B4 Q9H173	B3KP19 D6RI00 P30281 Q5T8J1
PDB IDs			3G33
Enriched GO Terms of Interacting Partners?
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