NFKBIZ and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		NFKBIZ	NFKB2
Description		NFKB inhibitor zeta	nuclear factor kappa B subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Positive Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 17 Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs			Acetylsalicylic acid Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide
Diseases
GWAS		Multiple sclerosis ( 21833088) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Spatial memory ( 31596458) Ulcerative colitis ( 26192919)	Metabolite levels ( 23823483) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: NFKB1 NFKB2 STAT3	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		64332	4791
HPRD ID		09217	01239
Ensembl ID		ENSG00000144802	ENSG00000077150
Uniprot IDs		Q9BYH8	Q00653
PDB IDs			1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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