NSD1 and TNFRSF21

Number of citations of the paper that reports this interaction (PubMedID 15623156)
0

Data Source:
BioGRID (pull down)

		NSD1	TNFRSF21
Description		nuclear receptor binding SET domain protein 1	TNF receptor superfamily member 21
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Axon Intrinsic Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	B Cell Apoptotic Process Adaptive Immune Response Apoptotic Process Humoral Immune Response Axonal Fasciculation Regulation Of Lipid Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Myelination Negative Regulation Of T Cell Proliferation Myelination Regulation Of Oligodendrocyte Differentiation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Cellular Response To Tumor Necrosis Factor Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion Negative Regulation Of Interleukin-10 Secretion
Pathways		PKMTs methylate histone lysines	PPARA activates gene expression
Drugs
Diseases		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Panic disorder ( 19165232) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122)
Interacting Genes		32 interacting genes: AR ATRX ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RTN4 RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	6 interacting genes: CLIP3 MATR3 NSD1 STX11 TRADD WASH2P
Entrez ID		64324	27242
HPRD ID		09455	05759
Ensembl ID		ENSG00000165671	ENSG00000146072
Uniprot IDs		Q96L73 Q96MN8	A0A024RD71 O75509
PDB IDs		3OOI	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
Enriched GO Terms of Interacting Partners?
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