RNF25 and UBE2L6

Number of citations of the paper that reports this interaction (PubMedID 19690564)
57

Data Source:
BioGRID (two hybrid)

		RNF25	UBE2L6
Description		ring finger protein 25	ubiquitin conjugating enzyme E2 L6
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GO Annotations	Cellular Component	Nucleus Cytosol	Ubiquitin Ligase Complex Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding NF-kappaB Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Blood protein levels ( 28240269)
Interacting Genes		9 interacting genes: CHPF RELA TRIM27 UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBE2L6 UBE2U	38 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA1 UBA6 UBA7 UBE3A
Entrez ID		64320	9246
HPRD ID		09737	04867
Ensembl ID		ENSG00000163481	ENSG00000156587
Uniprot IDs		Q96BH1	O14933
PDB IDs		2DAY 2DMF 5D1K 5D1L 5D1M	1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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