ABCG8 and ANG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCG8	ANG
Description		ATP binding cassette subfamily G member 8	angiogenin
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleolus Actin Cytoskeleton Growth Cone Cytoplasmic Vesicle Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Protein Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Metal Ion Binding Protein Heterodimerization Activity Intermembrane Cholesterol Transfer Activity	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding Protein Homodimerization Activity
	Biological Process	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Adherens Junction Organization Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion RNA Phosphodiester Bond Hydrolysis
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Adherens junctions interactions
Drugs			Pidolic Acid Citric Acid
Diseases		Sitosterolemia	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 28270201 25961943 20686565) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 30325047 30504769 30692554 27094239 17632509) LDL cholesterol ( 23726366 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Total cholesterol levels ( 30275531)	Blood protein levels ( 30072576 28240269)
Interacting Genes		8 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1	8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8
Entrez ID		64241	283
HPRD ID		05679	00105
Ensembl ID		ENSG00000143921	ENSG00000214274
Uniprot IDs		Q9H221	P03950 W0UV28
PDB IDs		5DO7	1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
Enriched GO Terms of Interacting Partners?
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