MMS19 and NCOA3

Number of citations of the paper that reports this interaction (PubMedID 11279242)
24

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MMS19	NCOA3
Description		MMS19 homolog, cytosolic iron-sulfur assembly component	nuclear receptor coactivator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cytoplasm Spindle Cytosol Membrane MMXD Complex CIA Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Enzyme Binding Receptor Signaling Complex Scaffold Activity Estrogen Receptor Binding Protein Binding, Bridging	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding Disordered Domain Specific Binding
	Biological Process	Phosphorelay Signal Transduction System DNA Metabolic Process DNA Repair Nucleotide-excision Repair Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromosome Segregation Response To Hormone Positive Regulation Of Signal Transduction Iron-sulfur Cluster Assembly Positive Regulation Of Transcription, DNA-templated Protein Maturation By Iron-sulfur Cluster Transfer Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Regulation Of RNA Biosynthetic Process
Pathways		Cytosolic iron-sulfur cluster assembly	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		8 interacting genes: ESR1 ESR2 GTF2H1 MAGEF1 MTNR1A NCOA3 RARA THRB	81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		64210	8202
HPRD ID		17579	03570
Ensembl ID		ENSG00000155229	ENSG00000124151
Uniprot IDs		Q96T76	Q59EE8 Q9Y6Q9
PDB IDs			1KBH 3L3X 3L3Z 6ES7
Enriched GO Terms of Interacting Partners?
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